Prozac doesn't work better than placebo
February 25, 2008 4:58 PM Subscribe
posted by Rumple (86 comments total)
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A new peer-reviewed meta-analysis of clinical data
demonstrates that four widely-prescribed SSRI anti-depressants, including Prozac and Effexor, are not more effective than placebos. Summary
from the Guardian.The review breaks new ground because Kirsch and his colleagues have obtained for the first time what they believe is a full set of trial data for four antidepressants.
They requested the full data under freedom of information rules from the Food and Drug Administration, which licenses medicines in the US and requires all data when it makes a decision.
The pattern they saw from the trial results of fluoxetine (Prozac), paroxetine (Seroxat), venlafaxine (Effexor) and nefazodone (Serzone) was consistent. "Using complete data sets (including unpublished data) and a substantially larger data set of this type than has been previously reported, we find the overall effect of new-generation antidepressant medication is below recommended criteria for clinical significance," they write.