They figured out a thing!
September 17, 2023 6:58 PM Subscribe
She wrote to a scientist about her fatigue. It inspired a breakthrough: Her dogged efforts lead to a new scientific discovery that may help others with long covid and other chronically fatiguing illnesses (For those who aren't reading things that include animal research, this contains animal research) (Archive.org, abstract)
Chronic fatigue is a debilitating symptom that affects many individuals, but its mechanism remains poorly understood. This study shows that endoplamic reticulum (ER) stress–induced WASF3 protein localizes to mitochondria and disrupts respiratory supercomplex assembly, leading to decreased oxygen consumption and exercise endurance. Alleviating ER stress decreases WASF3 and restores mitochondrial function, indicating that WASF3 can impair skeletal muscle bioenergetics and may be targetable for treating fatigue symptoms.