"The persistence of HIV is partially due to the ability of the virus to disable the cell’s altruistic suicide pathway, which is normally activated when a cell becomes infected or damaged."The research team has not yet conducted clinical trials on humans to study Ciclopirox as a topical HIV treatment, but the regulatory approval process is likely to be faster because the drug has already been approved by the FDA for other uses.
"[Ciclopirox] works against HIV in two ways: It inhibits the expression of HIV genes and also blocks the essential function of the mitochondria, thereby reactivating the cell’s suicide pathway. Healthy, uninfected cells examined during this study were spared."
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