For instance, sertraline (Zoloft) was the sixth best-selling medication in the US in 2004, with over $3 billion in sales  likely due, at least in part, to the widely disseminated advertising campaign starring Zoloft's miserably depressed ovoid creature.
With direct proof of serotonin deficiency in any mental disorder lacking, the claimed efficacy of SSRIs is often cited as indirect support for the serotonin hypothesis. Yet, this ex juvantibus line of reasoning (i.e., reasoning “backwards” to make assumptions about disease causation based on the response of the disease to a treatment) is logically problematic—the fact that aspirin cures headaches does not prove that headaches are due to low levels of aspirin in the brain. Serotonin researchers from the US National Institute of Mental Health Laboratory of Clinical Science clearly state, “[T]he demonstrated efficacy of selective serotonin reuptake inhibitors…cannot be used as primary evidence for serotonergic dysfunction in the pathophysiology of these disorders”.
Reasoning backwards, from SSRI efficacy to presumed serotonin deficiency, is thus highly contested.
a half a billion dollars were spent to market Nexium
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