Birds in Books. "Pennsylvania artist and designer Paula Swisher takes doodling in the margins of old engineering and science manuals to new heights. She began the illustrations using nothing but ballpoint pen and white-out similar to Mark Powell’s envelopes, but soon explored new materials including colored pencil, gouache and other mixed media like thread and cut-out paper."
More illustrations on her flickr. posted by sweetkid at 3:21 PM PST - 10 comments
Professor Brian Cox (previously 1 2) goes unplugged in a specially recorded programme from the lecture theatre of the Royal Institution of Great Britain. In his own inimitable style, Brian takes an audience of famous faces, scientists and members of the public on a journey through some of the most challenging concepts in physics. [more inside] posted by lazaruslong at 3:20 PM PST - 40 comments
FallingSTAR*D?: It is common practice for psychiatrists to switch depressive patients between different antidepressants if their current drug does not evince a symptomatic response. Despite clinical wisdom supporting this, little empirical, controlled evidence exists to direct “switching” protocols (e.g. if a patient with Z characteristics is on drug X, is it usually better to switch to drug A, B, or C? Will switching help at all?) in the psychopharmacological treatment of depression. The NIMH-funded STAR*D (Sequenced Alternatives to Relieve Depression) study aimed to address these questions of treatment direction in a very large (n>4000), “real-world” sample using a multi-phase treatment plan with different drugs (and cognitive therapy) at every step to maximize chances of eventual remission. Overall, the NIMH reported that about 67% of patients eventually achieved remission, with few differences in effectiveness between different types of treatment at each step. However, researchers and commentators have raised concerns regarding inconsistent reporting of outcomes, after-the-fact changes in study design and analysis, and other issues that may have inflated, partially invalidated, or misrepresented widely reported treatment outcomes. These inequities may also have implications for the secondary moderator analyses (i.e. does trait A predict switching to X or Y is better?) that were a major reason for the study. [more inside] posted by Keter at 12:16 PM PST - 12 comments